Adam R. Hersperger, Ph.D.
Associate Professor of Biology; Department Chair
Science Building room 145
- Ph.D. – University of Pennsylvania (Cell and Molecular Biology; Microbiology, Virology, and Parasitology concentration)
- B.S. – Bucknell University (Cell Biology and Biochemistry)
Areas of Expertise
- Vertebrate immune systems
- Ectromelia virus (“mousepox”) and other poxviruses
- Virus/host interactions
Areas of Research
Recent Publications: (underlined names below indicate undergraduate student co-authors)
- Morgis RA, Haan K, Schrey JM, Zimmerman RM, Hersperger AR. The epidermal growth factor ortholog of ectromelia virus activates EGFR/ErbB1 and demonstrates mitogenic function in vitro. Virology 2021.
- Forsyth KS, Roy NH, Peauroi E, DeHaven BC, Wold ED, Hersperger AR, Burkhardt JK, Eisenlohr LC. Ectromelia-encoded virulence factor C15 specifically inhibits antigen presentation to CD4+ T cells post peptide loading. PLOS Pathogens 2020.
- Frey TR, Forsyth KS, Sheehan MM, DeHaven BC, Pevarnik JG, Hand ES, Pizzorno MC, Eisenlohr LC, Hersperger AR. Ectromelia virus lacking the E3L ortholog is replication-defective and nonpathogenic but does induce protective immunity in a mouse strain susceptible to lethal mousepox. Virology 2018.
- Frey TR, Lehmann MH, Ryan CM, Pizzorno MC, Sutter G, Hersperger AR. Ectromelia virus accumulates less double-stranded RNA compared to vaccinia virus in BS-C-1 cells. Virology 2017.
- Hand ES, Haller SL, Peng C Rothenburg S, Hersperger AR. Ectopic expression of vaccinia virus E3 and K3 cannot rescue ectromelia virus replication in rabbit RK13 cells. PLOS ONE 2015.
- Hersperger AR, Siciliano NA, DeHaven BC, Snook AE, Eisenlohr LC. Epithelial immunization induces polyfunctional CD8+ T-cells and optimal mousepox protection. Journal of Virology 2014.
- Siciliano NA, Hersperger AR, Lacuanan AM, Xu R, Sidney J, Sette A, Sigal LJ, Eisenlohr LC. Impact of distinct poxvirus infections on the specificities and functionalities of CD4+ T-cell responses. Journal of Virology 2014.
Recent Student Independent Research Projects:
- Megan Keller ’23, Julie Schrey ’21, Michelle Nahrgang ’20, Rose Zimmerman ’19, Kaylyn Haan ’19, Rebecca Morgis ’19, and Sarah Boothman ’18: “Characterization of an epidermal growth factor ortholog encoded by ectromelia virus”
- Julia Pevarnik ’19, Maura Sheehan ’17, and Devin Fisher ’15: “Understanding the mechanism of CD4 T-cell inhibition by ectromelia virus protein B22”
- Colton Ryan ’16 and Tiffany Frey ’17: “Ectromelia virus accumulates less double-stranded RNA compared to vaccinia virus”
- Erin Hand ’15: “Characterization of a mutant ectromelia virus lacking the ability to interfere with dsRNA recognition by host cells”
- Stephanie McMaster ’14: “The study of microtubule dynamics following ectromelia virus infection of mammalian cells in culture”
For more information about the Hersperger Lab, please click here.
BIO 101: Concepts and Connections in Biology
BIO 203: Introduction to Genetics
BIO 321: Microbiology
BIO 325: Molecular Genetics
BIO 329: Virology
BIO 498: Immunology
Awards and Grants
- Teacher of Undergraduate Students Registration Award, American Society for Virology (ASV) annual meeting (2021)
- Teacher of Undergraduate Students Travel Award, ASV annual meeting (2018)
- Annadora Vesper Shirk Award for Faculty Scholarship, Albright College (2017)
- Phi Beta Kappa, Bucknell University (2005)
- R01 grant (#AI110542-01A1), Co-principal Investigator (National Institute of Allergy and Infectious Diseases)
Project period: July 2015 to December 2019
Project title: “MHCII cross-presentation as a driver of CD4+ T-cell responses to poxviruses”