The Merner-Pfeiffer-Klein Memorial Chapel, constructed in 1958, is the largest meeting space on campus, seating 900 people. It is also a popular place to hold lectures and events. The interior of Memorial Chapel was renovated in 2008 and new seating installed. New risers and stage extensions were added in 2010.

The statue in front of the Chapel is of Jacob Albright, after whom the College is named. Albright is affiliated with the United Methodist church, but is a multi-faith community.

The Chapel houses the philosophy and religious studies departments, as well as the Chaplain's Office.

The Catholic chaplain offers confession every Sunday at 6 p.m. in Kachel Chapel (Teel Hall) and celebrates Mass every Sunday at 6:30 p.m. in Kachel Chapel. A nondenominational, Protestant praise service takes place every Sunday at 2 p.m. in Kachel Chapel.

Organizations contributing to the vibrant spiritual life on campus include Hillel, the Moslem Student Association, Zen Buddhist practice, Tibetan Buddhist practice, Albright Christian Fellowship, the Albright College Gospel Choir, the Phil Berrigan Institute for Nonviolence, the Open Tent, the Interfaith Youth Core, SHADOW (prevention of violence against women), and the Albright College Gay/Straight Alliance.